plotOptimResultsPan: Plots the data and simulated values from any CellNOptR...

In cokelaer/CellNOptR: Training of boolean logic models of signalling networks using prior knowledge networks and perturbation data

Description

This function plots the data and simulated values according to each experiment in CNOlist. The data is shown as black triangles and the simulation by a blue dashed line. The combination of cues is given by a panel where black denotes the presence and white the absence of the cue. The goodness-of-fit between model and data is color-coded on a continuous scale from white to red.

Usage

plotOptimResultsPan(simResults, yInterpol=NULL, xCoords=NULL,
CNOlist=CNOlist, formalism=c("ss1","ss2","ssN","dt","ode"), pdf=FALSE,
pdfFileName="", tPt=NULL, 
plotParams = list(margin = 0.1, width=15, height=12, cmap_scale=1, cex=1.6,
ymin=NULL))

Arguments

simResults	A list with a field for each time point, each containing a matrix of dimensions (number of conditions) * (number of signals), with the first field being t0. Typically produced by simulating a model and then extracting the columns that correspond to signals.
yInterpol	If using CNORdt, these are the interpolated experimental results from getFitTimeScale() that are needed to compare against the Boolean simulation.
xCoords	These are the x-coordinates obtained from the optimized scaling factor in CNORdt that allow for comparison between time course experimental data and a Boolean model.
CNOlist	A CNOlist.
formalism	An abbreviation of the CellNOptR formalism being used.
pdf	A Boolean argument denoting whether to print the figure produced by this function to file.
pdfFileName	If printing to file, the filename to be used.
tPt	The number of time points in the data.
plotParams	a list of option related to the PDF and plotting outputs. Currently, the following attributes are used: (1) margin of the boxes, (2) width and heigth used while creating the PDF, (3) cmap_scale a value that scales the colors towards small errors (<1) or large errors (>1); default is 1 (linear colormap) (4) cex is the fontsize used in the header (5) ymin sets the minimum y axis limit; by default it is the minimum value found over all data points and therefore can be negative.

Details

Depending on the logic formalism, this function is generally called from cutAndPlotResults*(). As shown in the example below however, it can plot the fit of any data and corresponding compatible model. The color denotes the goodness-of-fit, where white shows no difference between simulation and data and red is the maximum error from all conditions and readouts.

Value

This function does not return a value.

Author(s)

A. MacNamara

References

J. Saez-Rodriguez, L. G. Alexopoulos, J. Epperlein, R. Samaga, D. A. Lauffenburger, S. Klamt and P. K. Sorger. Discrete logic modeling as a means to link protein signaling networks with functional analysis of mammalian signal transduction, Molecular Systems Biology, 5:331, 2009.

See Also

cutAndPlotResultsT1

Examples

data(CNOlistToy,package="CellNOptR")
data(ToyModel,package="CellNOptR")
indicesToy <- indexFinder(CNOlistToy, ToyModel, verbose=TRUE)
ToyFields4Sim <- prep4sim(ToyModel)

# simulate model
simRes <- simulatorT1(CNOlist=CNOlistToy, model=ToyModel, simList=ToyFields4Sim, indexList=indicesToy)
simRes = simRes[, indicesToy$signals]

# format data and results

simResults <- list(t0=matrix(data=0, nrow=dim(simRes)[1], ncol=dim(simRes)[2]), t1=simRes)
# plot
plotOptimResultsPan(simResults,
  CNOlist=CNOlistToy,
  formalism="ss1",
  pdf=FALSE,
  tPt=10
)

cokelaer/CellNOptR documentation built on May 27, 2019, 8:44 a.m.