Description Usage Format Examples
Observed expression measured at several dose levels for multiple runs.
1 |
A data frame with 63 observations on the following 3 variables.
run
ID of 3 different runs
dose
5 dose levels (0, 0.1, 10, 100, 500)
expression
observed expression
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 | data(Cyp17)
# transforming the vector of observed expression
Cyp17$logexpression <- log(Cyp17$expression) + 5
# assuming a 4-parameter log-logistic model
# upper asymptote fixed at 2.59
# random run effects on the lower asymptote and the ED50
Cyp17.LL4.mixed <- medrm(logexpression ~ dose,
random = c + e ~ 1 | run,
fct = LL.4(fixed = c(NA,NA,-2.41 + 5,NA)),
data = Cyp17,
start=c(-0.5, -4 + 5, 700))
plot(Cyp17.LL4.mixed, logx=TRUE) +
theme_classic()
plot(Cyp17.LL4.mixed, logx=TRUE, ranef=TRUE) +
theme_classic()
summary(Cyp17.LL4.mixed)
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