Epihet: Epigenetic heterogeneity from DNA methylation

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Epihet calculates a the PIM score, which measures the epigenetic heterogeneity in a bisulfite sequencing sample. Under the assumption that a homogeneous sample will have mostly CpGs with either 100% or 0% DNA methylation, it follows that the proportion of sites that differ from these two extremes can be used as a measure of sample heterogeneity.


Install the development version of epihet directly from GitHub:


or locally after downloading/cloning the source code:

install.packages("path/to/epihet/directory", repos=NULL, type="source")

How to use

Please see the vignettes for details.

databio/RPIM documentation built on May 14, 2019, 2:41 p.m.