databio/RPIM: Assess epigenetic heterogeneity with proportion of intermediate methylation

Provides a score called PIM that measures the epigenetic heterogeneity in a bisulfite sequencing sample. Under the assumption that a homogeneous sample will have mostly CpGs with either 100% or 0% DNA methylation, it follows that the proportion of sites that differ from these two extremes can be used as a measure of sample heterogeneity.

Getting started

Package details

Bioconductor views Bayesian Coverage DNAMethylation Epigenetics MethylSeq Sequencing
MaintainerVP Nagraj <[email protected]>
LicenseGPL-3
Version0.1.0
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
install.packages("remotes")
remotes::install_github("databio/RPIM")
databio/RPIM documentation built on May 14, 2019, 2:41 p.m.