parseRaoHiCtoGI: Parse Hi-C interactions from Rao et. al 2014 as...

Description Usage Arguments Value

Description

This function parses interactions from a single experiment by a given resolution. It takes a path to a directory with uncompressed raw data and subdirectories for each cell-type. The data can be manually downloaded and from this url: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE63525.

Usage

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parseRaoHiCtoGI(cell, resolution, baseDir, seqInfo, interChromosomal = TRUE,
  normalizeByExpected = FALSE, mapQual = "MAPQGE30", norm = NULL)

Arguments

cell

The cell type of the input experiment

resolution

The matrix resolution of the Hi-C map in bp

baseDir

The path to the directory with the Hi-C data.

seqInfo

A seqinfo object of the genome.

interChromosomal

logical idicating whether inter-chromosomal contacts should be parsed.

normalizeByExpected

Should contact frequencies be normalized by distance. Default is FALSE.

mapQual

character representing the mapping quality threshold. Defualt is "MAPQGE30".

norm

character representation of the normalization method to use. Default is NULL meaning that no normalization is applied. Possible values are "KR" or "VC". This is not impplemented yet.

Value

GInteractions object with all cis- and trans-interactions


ibn-salem/chromint documentation built on May 18, 2019, 1:29 a.m.