inheritance: Collapsing (or recoding) genotypes into different categories...

Description Usage Arguments Examples

Description

codominant function recodifies a variable having genotypes depending on the allelic frequency in descending order.

dominant, recessive, and overdominant functions collapse the three categories of a given SNP into two categories as follows: Let 'AA', 'Aa', and 'aa' be the three genotypes. After determining the most frequent allele (let's suppose that 'A' is the major allele) the functions return a vector with to categories as follows. dominant: 'AA' and 'Aa-aa'; recessive: 'AA-Aa' and 'aa'; overdominant: 'AA-aa' vs 'Aa'.

additive function creates a numerical variable, 1, 2, 3 corresponding to the three genotypes sorted out by descending allelic frequency (this model is referred as log-additive).

Usage

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Arguments

o

categorical covariate having genotypes

Examples

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data(SNPs)
dominant(snp(SNPs$snp10001,sep=""))
overdominant(snp(SNPs$snp10001,sep=""))

isglobal-brge/SNPassoc documentation built on April 7, 2018, 1:11 p.m.