ttmake: Create a topTable for limma with "msd" based on confidence...

In january3/myfuncs: loads a few functions I often need

Create a topTable for limma with "msd" based on confidence interval

Description

Create a topTable for limma with "msd" based on confidence interval

Usage

ttmake(fit, coef = 1, sort = TRUE, ...)

Arguments

fit	lmFit object
coef	coefficient for which the output should be generated
sort	whether the output should be sorted
...	any other parameter passed to topTable

Details

Create a topTable for limma with the additional column "msd" based on confidence interval.

msd is defined as the lower boundary of the confidence interval for the logFC, multiplied by the sum of the logFC. This allows to sort the list of genes by both the confidence we have in the predicted logFC and its magnitude, rather than by p-value alone (which can correspond to an small effect size) and logFC (which can be very variable despite a large estimate).

january3/myfuncs documentation built on Jan. 16, 2025, 8:37 p.m.