music.iter.ct: Scaling bulk data and signature matrix and estimate cell type...

In kalpita23/scRNA_package: Multi-subject single cell deconvolution

Description

Scaling bulk data and signature matrix and estimate cell type proportion

Usage

music.iter.ct(
  Y,
  D,
  S,
  Sigma.ct,
  iter.max = 1000,
  nu = 1e-04,
  eps = 0.01,
  centered = FALSE,
  normalize = FALSE
)

Arguments

Y	vector of bulk tissue expression
S	vector of Avg. Library size
Sigma.ct	matrix of Subject level variation with cross-cell-type covariance.
iter.max	numeric, maximum iteration number. Default is 1000
nu	regulation parameter, take care of weight when taking recipical by default nu = 0.0001.
eps	Thredshold of convergence. Default is 0.01.
centered	logic, substract avg of Y and D. Default is FALSE.
normalize	logic, divide Y and D by their standard deviation. Default is FALSE
X	matrix, Signature matrix

Value

a list same as nnls.weight.basic

kalpita23/scRNA_package documentation built on June 26, 2020, 12:15 a.m.