music.iter: Scaling bulk data and signature matrix and estimate cell type...

In kalpita23/scRNA_package: Multi-subject single cell deconvolution

Description

Scaling bulk data and signature matrix and estimate cell type proportion

Usage

music.iter(
  Y,
  D,
  S,
  Sigma,
  iter.max = 1000,
  nu = 1e-04,
  eps = 0.01,
  centered = FALSE,
  normalize = FALSE
)

Arguments

Y	vector of bulk tissue expression
D	matrix, Signature matrix
S	vector of Avg. Library size
Sigma	matrix of subject level variation (gene * cell type)
iter.max	numeric, maximum iteration number
nu	regulation parameter, when take recipical
eps	thredshold of converagence
centered	logic, substract avg of Y and D
normalize	logic, divide Y and D by their standard deviation

Value

a list same as nnls.weight.basic

kalpita23/scRNA_package documentation built on June 26, 2020, 12:15 a.m.