Man pages for kdkorthauer/MADGiC
Fits an empirical Bayesian hierarchical model to obtain posterior probabilities that each gene is a driver.

calculate.bijCalculate the background mutation probability for every...
calculate.post.probsCalculate posterior probability of being a driver
compRatioCubic spline logistic regression
convert.hgnc.to.ensemblConvert HGNC symbols to Ensembl identifiers using biomaRt
convert.seq.to.numConvert nucleotide sequence to numbers
dCG.typeGet mutation type (5-6) of CpG mutations
exomeExome annotation for human genome build NCBI 36/hg18
find.prior.paramFind the maximum likelihood values for the hyperparameters...
fit.background.modelFit background mutation model
gene_namesEnsembl names for all genes in the exome
generate.sel.exomeSelect the part of exome.constants that belongs to a list of...
gene.rep.exprGene annotation list
getACompute A - the likelihood of a mutation at every position
get.post.probsMain posterior probability calculation
locfdrEstimation of non-null density
lupost2.vecLikelihood of sample specific mutation rate given the...
lupost3.vecLikelihood of sample specific mutation rate given the...
lupost4.vecPosterior mean of sample-specific mutation rate given the...
lupost.vecLikelihood of mutations in a single gene and sample given the...
multiply.p.s.epsilonMultiply the constants in 'exome.constants' by the relative...
multiplyrMultiply the nonsilent constants in a subsetted...
mut.baseConvert nucleotide sequence to column numbers in 'exome.SIFT'
mut.lik.changeCalculate change in likelihood due to background mutations
mut.typeGet mutation type (transition or transversion)
mut.type.converterGet total counts of mutations for each replication timing,...
no.dCG.typeGet mutation type (1-4) of non-CpG mutations
numberConvert chromosome names (character) to numeric
OV.mafTCGA Ovarian MAF (Mutation Annotation Format) file
preprocess.BMPull out sequences, CpG dinucleotide positions, and base...
priorPrior probabilities that each gene is a passenger
shuffle.mutsSimulate new dataset
sift.colRetrieve the column from SIFT oject correspoinding to mutated...
sift.colARetrieve the column from SIFT oject correspoinding to mutated...
kdkorthauer/MADGiC documentation built on June 13, 2020, 1:35 p.m.