prior: Prior probabilities that each gene is a passenger

In kdkorthauer/MADGiC: Fits an empirical Bayesian hierarchical model to obtain posterior probabilities that each gene is a driver.

Description

This data set is a named vector of prior probabilities that each gene is a passenger. It was obtained using positional data in COSMIC (v66), such that the baseline prior probability was set to 0.99 and this probability was decreased for genes that showed evidence of either tumor suppressor activity (mutations clustering at the same amino acid positions) or oncogenic activity (a higher proportion of truncating mutations than the overall proportion).

Format

A vector of length 18,926 where each element corresponds to a gene and the name of the element is the Ensembl id. The numeric value lies between 0.5 and 0.99 and represents the prior probability that each gene is a passenger.

kdkorthauer/MADGiC documentation built on June 13, 2020, 1:35 p.m.