Description Details Author(s) Examples
In a given microarray experiment, this package computes a fisher-based enrichment of miRNA(s) depending on the enrichment of its target genes in the gene-set of interest (upregulation/downregulation) compared to background-set (invariably the <e2><80><9c>Expressed Genes<e2><80><9d>). It utilizes the TargetScan and microRNA datatbases for miRNA-target relationship.
Package: | miRNAEnrich |
Type: | Package |
Version: | 1.0 |
Date: | 2015-03-10 |
License: | GPL-3 |
Run the function mirna.enrich as given in the example.
Komal Rathi Maintainer: Komal Rathi <komalr@mail.med.upenn.edu>
1 2 3 4 5 6 7 8 | foreground <- background[which(background$fc < 0 & background$adj.P.Val<0.05),] #downregulated genes
res.microrna <- mirna.enrich(mir.db = 'microRNA',
org = 'mmu',
fg = foreground,
bg = background,
col = 'Symbol',
plot = TRUE,
cutoff = -0.1)
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