HyperGEnrich: Over-representation test process

Description Usage Arguments

View source: R/HyperGEnrich.R

Description

Over-representation test process

Usage

1
2
3
4
5
6
7
8
9
HyperGEnrich(
  GeneSet = sigGene_All,
  Database = "",
  minOverlap = 4,
  pvalue_thres = 0.05,
  adj_pvalue_thres = 1,
  padj_method = "BH",
  NewDB = F
)

Arguments

GeneSet

A list object; Ideal input is object resulted from convertNformatID Each element is a gene set to be tested, should have different identifiers in columns, 1st column - ensembl id; 2nd - entrezid, Also should have a column "Sig" indicating significant or not, 1 - significant; 0 insignificant

Database

Indicate one of the dataset to be used; choose from c("go","kegg","interpro","mesh","msig","reactome")

minOverlap

Minimum overlap number of total genes and genes of a target pathway, default value is 4

pvalue_thres

Pvalue threshold of the Fisher's exact test. Refer to fisher.test

adj_pvalue_thres

Adjusted value threshold for multiple testing control.

padj_method

Adjusted pvalues; choose methods from c("holm", "hochberg", "hommel", "bonferroni", "BH", "BY","fdr", "none"). Refer to p.adjust

NewDB

If new database will be used, please do NewDB = T. Please make sure xxx.rda was generated using XXX_DB_Update() and is currently in the working directory.


liulihe954/EnrichKit documentation built on Oct. 10, 2020, 11:49 p.m.