R/data.R

In marie-alexandre/AUCcomparison: Statistical test - Between group comparison of AUC

#' HIV RNA Load Simulated Data for Delta AUC = 0
#' 
#' A dataset containing simulated data used in the accompanying paper to this package.
#' 
#' @description This dataset gives simulated longitudinal log-transformed HIV RNA load dynamics for two distinct groups of patients who interrupted their antiretroviral treatment at baseline (time=0).
#' The group 'Group1' was simulated to mimic a control group while the group 'Group2' gathers patients assigned to a treatment group.
#' Each group accounts for 20 patients and each of them were followed for 24 weeks with one measure every week. 
#' This dataset was simulated to obtain a similar area under the mean HIV RNA load curves, despite the difference of the mean dynamics shape.
#' 
#' @format A data frame with 4 columns and 1000 rows:
#' \tabular{ll}{
#' \code{id} \tab The subject id. \cr
#' \code{time} \tab Time of HIV RNA load measurements. \cr
#' \code{Group} \tab Treatment group. \cr
#' \code{VL} \tab The HIV RNA load measures. \cr
#' }
#' 
#' @examples 
#' HIV_Simu_Dataset_Delta0
"HIV_Simu_Dataset_Delta0"



#' HIV RNA Load Simulated Data for Delta AUC = 0 With Left-censored data
#' 
#' A dataset containing simulated data used in the accompanying paper to this package.
#' 
#' @description This dataset gives simulated longitudinal log-transformed HIV RNA load dynamics for two distinct groups of patients who interrupted their antiretroviral treatment at baseline (time=0).
#' The group 'Group1' was simulated to mimic a control group while the group 'Group2' gathers patients assigned to a treatment group.
#' Each group accounts for 20 patients and each of them were followed for 24 weeks with one measure every week. HIV RNA load values are left-censored due to a limit of detection (LOD), considering log10(50) as threshold value.
#' This dataset was simulated to obtain a similar area under the mean HIV RNA load curves, despite the difference of the mean dynamics shape (without considering the left-censorship).
#' 
#' @format A data frame with 4 columns and 1000 rows:
#' \tabular{ll}{
#' \code{id} \tab The subject id. \cr
#' \code{time} \tab Time of HIV RNA load measurements. \cr
#' \code{Group} \tab Treatment group. \cr
#' \code{VL} \tab The HIV RNA load measures. Measures are either equals to their true value (if VL > LOD) or to the LOD value (otherwise). \cr
#' \code{Cens} \tab The indicator of left-censoring: 1 if VLtrue <= LOD and 0 otherwise. \cr
#' }
#' 
#' @examples 
#' HIV_Simu_Dataset_Delta0_cens
"HIV_Simu_Dataset_Delta0_cens"



#' HIV RNA Load Simulated Data for Delta AUC = -0.1
#' 
#' A dataset containing simulated data used in the accompanying paper to this package.
#' 
#' @description This dataset gives simulated longitudinal log-transformed HIV RNA load dynamics for two distinct groups of patients who interrupted their antiretroviral treatment at baseline (time=0).
#' The group 'Group1' was simulated to mimic a control group while the group 'Group2' gathers patients assigned to a treatment group.
#' Each group accounts for 20 patients and each of them were followed for 24 weeks with one measure every week. 
#' This dataset was simulated to obtain a difference of area under the mean HIV RNA load curves between the two groups (AUC2 - AUC1) equals to -0.1 log10 cp/ml. 
#' 
#' @format A data frame with 4 columns and 1000 rows:
#' \tabular{ll}{
#' \code{id} \tab The subject id. \cr
#' \code{time} \tab Time of HIV RNA load measurements. \cr
#' \code{Group} \tab Treatment group. \cr
#' \code{VL} \tab The HIV RNA load measures. \cr
#' }
#' 
#' @examples 
#' HIV_Simu_Dataset_Delta01
"HIV_Simu_Dataset_Delta01"


#' HIV RNA Load Simulated Data for Delta AUC = -0.1 With Left-censored data
#' 
#' A dataset containing simulated data used in the accompanying paper to this package.
#' 
#' @description This dataset gives simulated longitudinal log-transformed HIV RNA load dynamics for two distinct groups of patients who interrupted their antiretroviral treatment at baseline (time=0).
#' The group 'Group1' was simulated to mimic a control group while the group 'Group2' gathers patients assigned to a treatment group.
#' Each group accounts for 20 patients and each of them were followed for 24 weeks with one measure every week. HIV RNA load values are left-censored due to a limit of detection (LOD), considering log10(50) as threshold value.
#' This dataset was simulated to obtain a difference of area under the mean HIV RNA load curves between the two groups (AUC2 - AUC1) equals to -0.1 log10 cp/ml. 
#' 
#' @format A data frame with 4 columns and 1000 rows:
#' \tabular{ll}{
#' \code{id} \tab The subject id. \cr
#' \code{time} \tab Time of HIV RNA load measurements. \cr
#' \code{Group} \tab Treatment group. \cr
#' \code{VL} \tab The HIV RNA load measures. Measures are either equals to their true value (if VL > LOD) or to the LOD value (otherwise). \cr
#' \code{Cens} \tab The indicator of left-censoring: 1 if VLtrue <= LOD and 0 otherwise. \cr
#' }
#' 
#' @examples 
#' HIV_Simu_Dataset_Delta01_cens
"HIV_Simu_Dataset_Delta01_cens"


#' HIV RNA Load Simulated Data for Delta AUC = -0.25
#' 
#' A dataset containing simulated data used in the accompanying paper to this package.
#' 
#' @description This dataset gives simulated longitudinal log-transformed HIV RNA load dynamics for two distinct groups of patients who interrupted their antiretroviral treatment at baseline (time=0).
#' The group 'Group1' was simulated to mimic a control group while the group 'Group2' gathers patients assigned to a treatment group.
#' Each group accounts for 20 patients and each of them were followed for 24 weeks with one measure every week. 
#' This dataset was simulated to obtain a difference of area under the mean HIV RNA load curves between the two groups (AUC2 - AUC1) equals to -0.25 log10 cp/ml. 
#' 
#' @format A data frame with 4 columns and 1000 rows:
#' \tabular{ll}{
#' \code{id} \tab The subject id. \cr
#' \code{time} \tab Time of HIV RNA load measurements. \cr
#' \code{Group} \tab Treatment group. \cr
#' \code{VL} \tab The HIV RNA load measures. \cr
#' }
#' 
#' @examples 
#' HIV_Simu_Dataset_Delta025
"HIV_Simu_Dataset_Delta025"


#' HIV RNA Load Simulated Data for Delta AUC = -0.25 With Left-censored data
#' 
#' A dataset containing simulated data used in the accompanying paper to this package.
#' 
#' @description This dataset gives simulated longitudinal log-transformed HIV RNA load dynamics for two distinct groups of patients who interrupted their antiretroviral treatment at baseline (time=0).
#' The group 'Group1' was simulated to mimic a control group while the group 'Group2' gathers patients assigned to a treatment group.
#' Each group accounts for 20 patients and each of them were followed for 24 weeks with one measure every week. HIV RNA load values are left-censored due to a limit of detection (LOD), considering log10(50) as threshold value.
#' This dataset was simulated to obtain a difference of area under the mean HIV RNA load curves between the two groups (AUC2 - AUC1) equals to -0.25 log10 cp/ml. 
#' 
#' @format A data frame with 4 columns and 1000 rows:
#' \tabular{ll}{
#' \code{id} \tab The subject id. \cr
#' \code{time} \tab Time of HIV RNA load measurements. \cr
#' \code{Group} \tab Treatment group. \cr
#' \code{VL} \tab The HIV RNA load measures. Measures are either equals to their true value (if VL > LOD) or to the LOD value (otherwise). \cr
#' \code{Cens} \tab The indicator of left-censoring: 1 if VLtrue <= LOD and 0 otherwise. \cr
#' }
#' 
#' @examples 
#' HIV_Simu_Dataset_Delta025_cens
"HIV_Simu_Dataset_Delta025_cens"