SIME_model: Model: SIME

In mathesong/kinfitr: Kinetic Modelling of PET Time Activity Curves

Model: SIME

Description

This is the SIME Model model itself by which predicted values are generated.

Usage

SIME_model(t_tac, input, Vnd, k2, k3, k4, vB)

Arguments

t_tac	Numeric vector of times for each frame in minutes. We use the time halfway through the frame as well as a zero.
input	Data frame containing the blood, plasma, and parent fraction concentrations over time. This can be generated using the blood_interp function. It should already be shifted if a shift is desired, using shift_timings.
Vnd	The specified Vnd value for the given ROI.
k2	Parameter value for k2
k3	Parameter value for k3
k4	Parameter value for k4
vB	Parameter value for vB

Value

A numeric vector of the predicted values of the TAC in the target region with the given Vnd.

Author(s)

Granville J Matheson, [e-mail]

References

Ogden RT, Zanderigo F, Parsey RV. Estimation of in vivo nonspecific binding in positron emission tomography studies without requiring a reference region. NeuroImage. 2015 Mar 31;108:234-42.

Examples

## Not run: 
SIME_model(t_tac, input, Vnd = 5, k2 = 0.1, k3 = 0.05, k4 = 0.04, vB = 0.05)

## End(Not run)

mathesong/kinfitr documentation built on Jan. 15, 2024, 11:07 p.m.