metab_hill: Fit a Hill Function to Model Parent Fraction

In mathesong/kinfitr: Kinetic Modelling of PET Time Activity Curves

Fit a Hill Function to Model Parent Fraction

Description

This function fits a classic Hill Function to parent fraction data.

Usage

metab_hill(
  time,
  parentFraction,
  fit_ppf0 = FALSE,
  fit_delay = FALSE,
  lower = list(a = 0, b = 1, c = 0, ppf0 = 0.8, delay = -30),
  upper = list(a = 1, b = 100, c = 100, ppf0 = 1.1, delay = 30),
  multstart_lower = NULL,
  multstart_upper = NULL,
  multstart_iter = 100
)

Arguments

time	Time in seconds.
parentFraction	Measured values of parent fraction.
fit_ppf0	Should the starting plasma parent fraction be fitted? Otherwise, it is set to 1. Defaults to FALSE.
fit_delay	Should the delay of the plasma parent fraction be fitted? Otherwise, it is set to 0. Defaults to FALSE.
lower	Named list of the lower limits.
upper	Named list of the upper limits.
multstart_lower	Named list of the lower starting limits.
multstart_upper	Named list of the upper starting limits.
multstart_iter	Number of fits to perform before deciding on an optimal.

Value

An nls fit object.

Examples

## Not run: 
pf <- bd_getdata(blooddata, output = "parentFraction")
metab_hill(pf$time, pf$parentFraction)

## End(Not run)

mathesong/kinfitr documentation built on Jan. 15, 2024, 11:07 p.m.