refmlLogan_tstar: Tstar Finder: Non-Invasive Multilinear Logan Plot

In mathesong/kinfitr: Kinetic Modelling of PET Time Activity Curves

Tstar Finder: Non-Invasive Multilinear Logan Plot

Description

Function to identify where t* is for the non-invasive multilinear Logan plot.

Usage

refmlLogan_tstar(
  t_tac,
  reftac,
  lowroi,
  medroi,
  highroi,
  k2prime,
  filename = NULL,
  frameStartEnd = NULL,
  gridbreaks = 2
)

Arguments

t_tac	Numeric vector of times for each frame in minutes. We use the time halfway through the frame as well as a zero. If a time zero frame is not included, it will be added.
reftac	Numeric vector of radioactivity concentrations in the reference tissue for each frame.
lowroi	Numeric vector of radioactivity concentrations in a target tissue for each frame. This should be from a ROI with low binding.
medroi	Numeric vector of radioactivity concentrations in a target tissue for each frame. This should be from a ROI with medium binding.
highroi	Numeric vector of radioactivity concentrations in a target tissue for each frame. This should be from a ROI with high binding.
k2prime	Value of k2prime to be used for the fitting, i.e. the average tissue-to-plasma clearance rate. This can be obtained from another model, or set at a specified value. If using SRTM to estimate this value, it is equal to k2 / R1.
filename	The name of the output image: filename_refmlLogan.jpeg
frameStartEnd	Optional: This allows one to specify the beginning and final frame to use for modelling, e.g. c(1,20). This is to assess time stability.
gridbreaks	Optional. The size of the grid in the plots. Default: 2.

Value

Saves a jpeg of the plots as filename_refmlLogan.jpeg

Author(s)

Granville J Matheson, [e-mail]

Examples

## Not run: 
refmlLogan_tstar(t_tac, reftac, taclow, tacmed, tachigh,
  k2prime = k2prime, "demonstration"
)

## End(Not run)

mathesong/kinfitr documentation built on Jan. 15, 2024, 11:07 p.m.