tidyinput_ref: Tidy Up for Reference Region Methods

In mathesong/kinfitr: Kinetic Modelling of PET Time Activity Curves

Tidy Up for Reference Region Methods

Description

Function to tidy up the input argument vectors for reference region models.

Usage

tidyinput_ref(t_tac, reftac, roitac, weights, frameStartEnd)

Arguments

t_tac	Numeric vector of times for each frame in minutes.
reftac	Numeric vector of radioactivity concentrations in the reference tissue for each frame.
roitac	Numeric vector of radioactivity concentrations in the target tissue for each frame.
weights	Optional. Numeric vector of the weights assigned to each frame in the fitting.
frameStartEnd	Optional. This allows one to specify the beginning and final frame to use for modelling, e.g. c(1,20).

Details

This function i) adds uniform weights if weights are not specified, ii) checks that the lengths of t_tac, reftac, roitac and weights are of the same length, iii) shortens the vectors if a frameStartEnd is specified, iv) adds a zero frame if there is not one, and v) checks that times are in minutes and not in seconds.

Value

A dataframe containing the tidied up t_tac, reftac, roitac and weights ready for modelling.

Author(s)

Granville J Matheson, [e-mail]

Examples

#' # Note: Reference region models, and irreversible binding models, should not
# be used for PBR28 - this is just to demonstrate function

data(pbr28)

t_tac <- pbr28$tacs[[2]]$Times / 60
reftac <- pbr28$tacs[[2]]$CBL
roitac <- pbr28$tacs[[2]]$STR
weights <- pbr28$tacs[[2]]$Weights

tidyinput_ref(t_tac, reftac, roitac, weights, frameStartEnd = c(1, 10))

mathesong/kinfitr documentation built on Jan. 15, 2024, 11:07 p.m.