#' Function to compute CI around the raw mean difference
#'
#' @param Group.1 a (non-empty) numeric vector of data values.
#' @param Group.2 a (non-empty) numeric vector of data values.
#' @param conf.level confidence level of the interval
#' @param var.equal a logical variable indicating whether to assume equality of population variances.
#' If TRUE the pooled variance is used to estimate the standard error. Otherwise, the standard error is estimated based on
#' unpooled variance.
#' @param alternative a character string specifying the alternative hypothesis, must be one of "two.sided" (default), "greater" or "less".
#' @param na.rm set whether Missing Values should be excluded (na.rm = TRUE) or not (na.rm = FALSE) - defaults to TRUE.
#'
#' @export datameandiff_CI
#'
#' @exportS3Method datameandiff_CI default
#' @exportS3Method print datameandiff_CI
#'
#' @keywords mean difference, confidence interval
#' @return Returns raw mean difference, (1-alpha)% confidence interval around mean difference, standard error
#' @importFrom stats na.omit sd pt uniroot
datameandiff_CI <- function(Group.1,Group.2,conf.level,var.equal,alternative,na.rm) UseMethod("datameandiff_CI")
datameandiff_CIEst <- function(Group.1,
Group.2,
conf.level=.95,
var.equal=FALSE,
alternative="two.sided",
na.rm=TRUE){
if (na.rm == TRUE ) {
Group.1 <- na.omit(Group.1)
Group.2 <- na.omit(Group.2)
} else {
Group.1 <- Group.1
Group.2 <- Group.2
}
if(inherits(Group.1,c("numeric","integer")) == FALSE |inherits(Group.2,c("numeric","integer")) == FALSE)
stop("Data are neither numeric nor integer")
n1 <- length(Group.1)
n2 <- length(Group.2)
m1 <- mean(Group.1)
m2 <- mean(Group.2)
sd1 <- sd(Group.1)
sd2 <- sd(Group.2)
if(alternative=="two.sided"){
if (var.equal==TRUE){
pooled_sd <- sqrt(((n1-1)*sd1^2+(n2-1)*sd2^2)/(n1+n2-2))
SE <- pooled_sd*sqrt(1/n1+1/n2) # standard error
# lower limit = limit of mu1-mu2 such as 1-pt(q=t_obs, df=df) = (1-conf.level)/2 = alpha/2
# with t_obs = ((m1-m2)-(theo_mudiff))/SE
f=function(theo_mudiff,rep) 1-pt(q=((m1-m2)-(theo_mudiff))/SE, df=n1+n2-2)-rep
out=uniroot(f,c(0,2),rep=(1-conf.level)/2,extendInt = "yes")
theo_mudiff.1 <- out$root
# upper limit = limit of mu1-mu2 such aspt(q=t_obs, df=df) = (1-conf.level)/2 = alpha/2
# with t_obs = ((m1-m2)-(theo_mudiff))/SE
f=function(theo_mudiff,rep) pt(q=((m1-m2)-(theo_mudiff))/SE, df=n1+n2-2)-rep
out=uniroot(f,c(0,2),rep=(1-conf.level)/2,extendInt = "yes")
theo_mudiff.2 <- out$root
result <- c(theo_mudiff.1, theo_mudiff.2)
} else if (var.equal==FALSE){
SE <- sqrt(sd1^2/n1+sd2^2/n2) # standard error
DF <- ((sd1^2/n1+sd2^2/n2)^2)/((sd1^2/n1)^2/(n1-1)+(sd2^2/n2)^2/(n2-1))
# lower limit = limit of mu1-mu2 such as 1-pt(q=t_obs, df=df) = (1-conf.level)/2 = alpha/2
# with t_obs = ((m1-m2)-(theo_mudiff))/SE
f=function(theo_mudiff,rep) 1-pt(q=((m1-m2)-(theo_mudiff))/SE, df=DF)-rep
out=uniroot(f,c(0,2),rep=(1-conf.level)/2,extendInt = "yes")
theo_mudiff.1 <- out$root
# upper limit = limit of mu1-mu2 such aspt(q=t_obs, df=df) = (1-conf.level)/2 = alpha/2
# with t_obs = ((m1-m2)-(theo_mudiff))/SE
f=function(theo_mudiff,rep) pt(q=((m1-m2)-(theo_mudiff))/SE, df=DF)-rep
out=uniroot(f,c(0,2),rep=(1-conf.level)/2,extendInt = "yes")
theo_mudiff.2 <- out$root
result <- c(theo_mudiff.1, theo_mudiff.2)
}
} else if (alternative == "greater"){
if (var.equal==TRUE){
pooled_sd <- sqrt(((n1-1)*sd1^2+(n2-1)*sd2^2)/(n1+n2-2))
SE <- pooled_sd*sqrt(1/n1+1/n2)
# Lower limit = limit of mu1-mu2 such as 1-pt(q=t_obs, df=df) = (1-conf.level) = alpha
# with t_obs = ((m1-m2)-(theo_mudiff))/SE
f=function(theo_mudiff,rep) 1-pt(q=((m1-m2)-(theo_mudiff))/SE, df=n1+n2-2)-rep
out=uniroot(f,c(0,2),rep=1-conf.level,extendInt = "yes")
theo_mudiff.1 <- out$root
# upper limit = +Inf
theo_mudiff.2 <- Inf # if our expectation is mu1 > mu2, then we expect that (mu1-mu2)> 0 and therefore
# we want to check only the lower limit of the CI
result <- c(theo_mudiff.1, theo_mudiff.2)
} else if (var.equal==FALSE) {
SE <- sqrt(sd1^2/n1+sd2^2/n2)
DF <- ((sd1^2/n1+sd2^2/n2)^2)/((sd1^2/n1)^2/(n1-1)+(sd2^2/n2)^2/(n2-1))
# Lower limit = limit of mu1-mu2 such as 1-pt(q=t_obs, df=DF) = (1-conf.level) = alpha
# with t_obs = ((m1-m2)-(theo_mudiff))/SE
f=function(theo_mudiff,rep) 1-pt(q=((m1-m2)-(theo_mudiff))/SE, df=DF)-rep
out=uniroot(f,c(0,2),rep=1-conf.level,extendInt = "yes")
theo_mudiff.1 <- out$root
# Upper limit = +Inf
theo_mudiff.2 <- Inf # if our expectation is mu1 > mu2, then we expect that (mu1-mu2)> 0 and therefore
# we want to check only the lower limit of the CI
result <- c(theo_mudiff.1, theo_mudiff.2)
}
} else if (alternative == "less"){
if (var.equal==TRUE){
pooled_sd <- sqrt(((n1-1)*sd1^2+(n2-1)*sd2^2)/(n1+n2-2))
SE <- pooled_sd*sqrt(1/n1+1/n2)
# Lower limit = - inf
theo_mudiff.1 <- -Inf # if our expectation is mu1 < mu2, then we expect that (mu1-mu2)< 0 and therefore
# we want to check only the upper limit of the CI
# Upper limit = limit of mu1-mu2 such as pt(q=t_obs, df=df) = (1-conf.level) = alpha
# with t_obs = ((m1-m2)-(theo_mudiff))/SE
f=function(theo_mudiff,rep) pt(q=((m1-m2)-(theo_mudiff))/SE, df=n1+n2-2)-rep
out=uniroot(f,c(0,2),rep=1-conf.level,extendInt = "yes")
theo_mudiff.2 <- out$root
result <- c(theo_mudiff.1, theo_mudiff.2)
} else if (var.equal==FALSE) {
SE <- sqrt(sd1^2/n1+sd2^2/n2)
DF <- ((sd1^2/n1+sd2^2/n2)^2)/((sd1^2/n1)^2/(n1-1)+(sd2^2/n2)^2/(n2-1))
# Lower limit = - inf
theo_mudiff.1 <- -Inf # if our expectation is mu1 < mu2, then we expect that (mu1-mu2)< 0 and therefore
# we want to check only the upper limit of the CI
# Upper limit = limit of mu1-mu2 such as pt(q=t_obs, df=DF) = (1-conf.level) = alpha
# with t_obs = ((m1-m2)-(theo_mudiff))/SE
f=function(theo_mudiff,rep) pt(q=((m1-m2)-(theo_mudiff))/SE, df=DF)-rep
out=uniroot(f,c(0,2),rep=1-conf.level,extendInt = "yes")
theo_mudiff.2 <- out$root
result <- c(theo_mudiff.1, theo_mudiff.2)
}
}
# print results
meth <- "Confidence interval around the raw mean difference"
# Return results in list()
invisible(
list(Meandiff = m1-m2,
conf.level = conf.level,
Std.error = SE,
CI = result)
)
}
# Adding a default method in defining a function called datameandiff_CI.default
datameandiff_CI.default <- function(
Group.1,
Group.2,
conf.level=.95,
var.equal=FALSE,
alternative="two.sided",
na.rm=TRUE){
out <- datameandiff_CIEst(Group.1,Group.2,conf.level,var.equal,alternative,na.rm)
out$Meandiff <- out$Meandiff
out$std.error <- out$std.error
out$call <- match.call()
out$CI <- out$CI
out$conf.level <- out$conf.level
class(out) <- "datameandiff_CI"
out
}
print.datameandiff_CI <- function(x,...){
cat("Call:\n")
print(x$call)
cat("\nRaw means difference :\n")
print(round(x$Meandiff,3))
cat(paste0("\n",x$conf.level*100," % confidence interval around the raw means difference:\n"))
print(round(x$CI,3))
}
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