gendr_linearcomb: Generate random combination dose response data using linear...

In mitchell-thomann/doseCombR:

Description

Generate random combination dose response data using linear models

Usage

gendr_linearcomb(type = "binomial", dose_1 = c(0, 2, 5, 10, 15, 30),
  dose_2 = c(0, 1, 2, 4), n_total = 240, e0 = -2.5, theta1 = 0.25,
  theta2 = 0.5, theta12 = 0)

Arguments

type	data type, only supports "binomial" currently
dose_1	vector of monotherapy investigational doses for drug 1
dose_2	vector of monotherapy investigational doses for drug 2
n_total	total number of subjects, (currently) assumes equivalent number of subjects per dose combination
e0	placebo effect, logit scale for binomial data
theta1	monotherapy slope for dose1, logit scale for binomial data
theta2	monotherapy slope for dose 2, logit scale for binomial data
theta12	interaction term, < 0 for antagonism, 0 for additivity, >0 for synergism

Value

tibble of dose response data

mitchell-thomann/doseCombR documentation built on May 24, 2019, 9:54 a.m.