data_asthma: An AB/BA crossover trial of treatments for bronchial asthma

In mjg211/xover: Design and analysis of cross-over clinical trials

Description

Quoted from Jones and Kenward (2014) (see page 55): "These data, which were originally given by Patel (1983), were reported as being taken from the results of a trial involving subjects with mild to acute bronchial asthma. The treatments were single doses of two active drugs and we will label them as A and B, respectively. The response of interest was the forced expired volume in one second (FEV1)."

Usage

data_asthma

Format

A tibble with 34 rows (observations) and 7 columns (variables):

fev1

A continuous outcome measurement. Stored as a double.

period

The period of the trial corresponding to each observation. Stored as a factor.

treatment

The administered treatment corresponding to each observation. Stored as a factor.

subject

The subject corresponding to each observation. Stored as a factor.

sequence

The treatment sequence for the subject corresponding to each observation. Stored as a factor.

'sequence index'

The treatment sequence index for the subject corresponding to each observation. Stored as a factor.

'baseline'

A period-specific continuous baseline measurement. Stored as a double.

Details

Data pertains to a trial with

• 2 treatments;

• 2 periods;

• 2 sequences;

• 17 subjects;

• 1 continuous outcome measurement;

• 1 period-specific continuous baseline measurements.

Source

Jones B, Kenward MG (2014) Design and Analysis of Cross-Over Trials. Chapman and Hall: London, 3rd Edition.

mjg211/xover documentation built on Oct. 16, 2019, 10:46 a.m.