data_copd: An AB/BA crossover trial of treatments for COPD

In mjg211/xover: Design and analysis of cross-over clinical trials

Description

Quoted from Jones and Kenward (2014) (see page 11): "These are data from a single-center, randomized, placebo-controlled, double blind study to evaluate the efficacy and safety of an inhaled drug (A) given twice daily via an inhaler in patients with chronic obstructive pulmonary disease (COPD)."

Usage

data_copd

Format

A tibble with 116 rows (observations) and 10 columns (variables):

pefr

A continuous outcome measurement. Stored as a double.

nam

A continuous outcome measurement. Stored as a double.

severity

A categorical outcome measurement. Stored as a factor.

period

The period of the trial corresponding to each observation. Stored as a factor.

treatment

The administered treatment corresponding to each observation. Stored as a factor.

subject

The subject corresponding to each observation. Stored as a factor.

sequence

The treatment sequence for the subject corresponding to each observation. Stored as a factor.

'sequence index'

The treatment sequence index for the subject corresponding to each observation. Stored as a factor.

'baseline nam'

A continuous pre-trial baseline measurement. Stored as a double.

'binary baseline nam'

A binary pre-trial baseline measurement. Stored as a factor.

Details

Data pertains to a trial with

• 2 treatments;

• 2 periods;

• 2 sequences;

• 58 subjects;

• 2 continuous and 1 categorical outcome measurement;

• 1 pre-trial continuous and 1 pre-trial binary baseline measurement.

Source

Jones B, Kenward MG (2014) Design and Analysis of Cross-Over Trials. Chapman and Hall: London, 3rd Edition.

mjg211/xover documentation built on Oct. 16, 2019, 10:46 a.m.