seq_bate_jones: Bate and Jones (2002) cross-over design specification
In mjg211/xover: Design and analysis of cross-over clinical trials

Description Usage Arguments Details Value Author(s) References Examples

Specifies cross-over designs from Bate and Jones (2002).

1 2	seq_bate_jones(D = 5, labels = 0:(D - 1), as_matrix = T, summary = T)

`D`	The number of treatments. Must be either five or eight. Defaults to `2`.
`labels`	A `vector` of labels for the treatments. Should be of `length` `D`, containing unique elements. Defaults to `0:(D - 1)`.
`as_matrix`	A `logical` variable indicating whether the design should be returned as a `matrix`, or a `tibble`. Defaults to `T`.
`summary`	A `logical` variable indicating whether a summary of the function's progress should be printed to the console. Defaults to `T`.

seq_bate_jones() supports the specification of cross-over designs from Bate and Jones (2002). Designs for five and eight treatments (see D) are supported, for any chosen treatment labels (see labels). In addition, the designs can be returned in matrix or tibble form (see as_matrix).

Precisely, the (k,j)th element of the cross-over design matrix corresponds to the treatment a subject on the kth sequence would receive in the jth period.

Either a matrix if as_matrix = T (with rows corresponding to sequences and columns to periods), or a tibble if as_matrix = F (with rows corresponding to a particular period on a particular sequence). In either case, the returned object will have class xover_seq.

Based on data from the Crossover package by Kornelius Rohmeyer.

Bate S, Jones B (2002) The construction of universally optimal uniform cross-over designs. GlaxoSmithKline Biomedical Data Sciences Technical Report.

# Bate and Jones (2002) design for five treatments
bate_jones        <- seq_bate_jones()
# Using different labels
bate_jones_ABCDE  <- seq_bate_jones(labels = LETTERS[1:5])
# Returning in tibble form
bate_jones_tibble <- seq_bate_jones(as_matrix = F)