add.dosing: Add dosing to eventTable

In nlmixrdevelopment/RxODE: Facilities for Simulating from ODE-Based Models

Description

This adds a dosing event to the event table. This is provided for piping syntax through magrittr

Usage

add.dosing(eventTable, dose, nbr.doses = 1L, dosing.interval = 24,
  dosing.to = 1L, rate = NULL, amount.units = NA_character_,
  start.time = 0, do.sampling = FALSE, time.units = NA_character_,
  ...)

Arguments

eventTable	eventTable object
dose	numeric scalar, dose amount in amount.units;
nbr.doses	integer, number of doses;
dosing.interval	required numeric scalar, time between doses in time.units, defaults to 24 of time.units="hours";
dosing.to	integer, compartment the dose goes into (first compartment by default);
rate	for infusions, the rate of infusion (default is NULL, for bolus dosing;
amount.units	optional string indicating the dosing units. Defaults to NA to indicate as per the original EventTable definition.
start.time	required dosing start time;
do.sampling	logical, should observation sampling records be added at the dosing times? Defaults to FALSE.
time.units	optional string indicating the time units. Defaults to "hours" to indicate as per the original EventTable definition.
...	Other parameters passed to et.

Value

eventTable with updated dosing (note the event table will be updated anyway)

Author(s)

Matthew L. Fidler

Matthew L Fidler, Wenping Wang

References

Wang W, Hallow K, James D (2015). "A Tutorial on RxODE: Simulating Differential Equation Pharmacometric Models in R." CPT: Pharmacometrics \& Systems Pharmacology, 5(1), 3-10. ISSN 2163-8306, <URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728294/>.

See Also

eventTable, add.sampling, add.dosing, et, etRep, etRbind, RxODE

Examples

## Model from RxODE tutorial
mod1 <-RxODE({
    KA=2.94E-01;
    CL=1.86E+01;
    V2=4.02E+01;
    Q=1.05E+01;
    V3=2.97E+02;
    Kin=1;
    Kout=1;
    EC50=200;
    C2 = centr/V2;
    C3 = peri/V3;
    d/dt(depot) =-KA*depot;
    d/dt(centr) = KA*depot - CL*C2 - Q*C2 + Q*C3;
    d/dt(peri)  =                    Q*C2 - Q*C3;
    d/dt(eff)  = Kin - Kout*(1-C2/(EC50+C2))*eff;
});

## These are making the more complex regimens of the RxODE tutorial

## bid for 5 days
bid <- et(timeUnits="hr") %>%
       et(amt=10000,ii=12,until=set_units(5, "days"))

## qd for 5 days
qd <- et(timeUnits="hr") %>%
      et(amt=20000,ii=24,until=set_units(5, "days"))

## bid for 5 days followed by qd for 5 days

et <- seq(bid,qd) %>% et(seq(0,11*24,length.out=100));

bidQd <- rxSolve(mod1, et)

plot(bidQd, C2)


## Now Infusion for 5 days followed by oral for 5 days

##  note you can dose to a named compartment instead of using the compartment number
infusion <- et(timeUnits = "hr") %>%
      et(amt=10000, rate=5000, ii=24, until=set_units(5, "days"), cmt="centr")


qd <- et(timeUnits = "hr") %>% et(amt=10000, ii=24, until=set_units(5, "days"), cmt="depot")

et <- seq(infusion,qd)

infusionQd <- rxSolve(mod1, et)

plot(infusionQd, C2)

## 2wk-on, 1wk-off

qd <- et(timeUnits = "hr") %>% et(amt=10000, ii=24, until=set_units(2, "weeks"), cmt="depot")

et <- seq(qd, set_units(1,"weeks"), qd) %>%
     add.sampling(set_units(seq(0, 5.5,by=0.005),weeks))

wkOnOff <- rxSolve(mod1, et)

plot(wkOnOff, C2)

## You can also repeat the cycle easily with the rep function

qd <-et(timeUnits = "hr") %>% et(amt=10000, ii=24, until=set_units(2, "weeks"), cmt="depot")

et <- etRep(qd, times=4, wait=set_units(1,"weeks")) %>%
     add.sampling(set_units(seq(0, 12.5,by=0.005),weeks))

repCycle4 <- rxSolve(mod1, et)

plot(repCycle4, C2)

nlmixrdevelopment/RxODE documentation built on Dec. 7, 2019, 2:33 a.m.