View source: R/use_ligand_to_target.R
extract_top_fraction_ligands | R Documentation |
extract_top_fraction_ligands
Get the predicted top n percentage ligands of a target of interest
extract_top_fraction_ligands(target_oi,top_fraction,ligand_target_matrix,ligands_position = "cols")
target_oi |
The target gene of interest of which top upstream ligands should be returned |
top_fraction |
A number between 0 and 1 indicating which top fraction of ligands should be returned. |
ligand_target_matrix |
A matrix of ligand-target probabilty scores. |
ligands_position |
Indicate whether the ligands in the ligand-target matrix are in the rows ("rows") or columns ("cols"). Default: "cols" |
A named numeric vector of ligand-target gene probability scores of the top ligands.
## Not run:
## Generate the ligand-target matrix from loaded weighted_networks
weighted_networks = construct_weighted_networks(lr_network, sig_network, gr_network,source_weights_df)
ligands = list("TNF","BMP2",c("IL4","IL13"))
ligand_target_matrix = construct_ligand_target_matrix(weighted_networks, ligands)
targets = extract_top_fraction_ligands("ID3",0.01,ligand_target_matrix)
## End(Not run)
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