dorothea_hs_pancancer: Human DoRothEA (pancancer)

dorothea_hs_pancancerR Documentation

Human DoRothEA (pancancer)

Description

A table reporting signed human TF-target interactions for cancer application. The difference to "dorothea_hs" is that TGCA gene expression data was used instead of GTEx to infer the networks with ARACNE. This database covers in total 1344 TFs targeting 20,582 genes with 213,230 unique interactions. In addition, each TF is accompanied with an empirical confidence level that was derived from the number of supporting evidences for this TF/interaction. The range is from A (high quality) to E (low quality).

Format

A table of human TF-target interactions:

tf

TF identifier as HGNC symbols

confidence

Summary confidence score classifying regulons based on their quality

target

target identifier as HGNC symbols

mor

mode of regulation indicating the effect of a TF on the target

Source

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673718/


saezlab/dorothea documentation built on Feb. 24, 2024, 8:12 p.m.