The GeneSurrounder method consists of two tests that are run independently of each other and then combined to determine if the putative disease gene is a “disruptive” candidate disease gene meeting both criteria.
1 2 | geneNIDG(distance.matrix, cor.matrix, geneStats.observed, perm.geneStats.matrix,
genes.assayedETnetwork, diameter, num.Sphere.resamples, gene.id)
|
distance.matrix |
A matrix of the distances on the global network |
cor.matrix |
A matrix of correlations between the expression of the genes |
geneStats.observed |
A vector of the observed differential expression |
perm.geneStats.matrix |
A matrix of the resampled differential expression |
genes.assayedETnetwork |
The names of the genes that are assayed and on the network |
diameter |
The diameter of the global network |
num.Sphere.resamples |
The number of resamples when running the Sphere of Influence Procedure |
gene.id |
The name of the gene to which GeneSurrounder is applied |
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