geneNIDG: GeneSurrounder wrapper

Description Usage Arguments

Description

The GeneSurrounder method consists of two tests that are run independently of each other and then combined to determine if the putative disease gene is a “disruptive” candidate disease gene meeting both criteria.

Usage

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geneNIDG(distance.matrix, cor.matrix, geneStats.observed, perm.geneStats.matrix,
  genes.assayedETnetwork, diameter, num.Sphere.resamples, gene.id)

Arguments

distance.matrix

A matrix of the distances on the global network

cor.matrix

A matrix of correlations between the expression of the genes

geneStats.observed

A vector of the observed differential expression

perm.geneStats.matrix

A matrix of the resampled differential expression

genes.assayedETnetwork

The names of the genes that are assayed and on the network

diameter

The diameter of the global network

num.Sphere.resamples

The number of resamples when running the Sphere of Influence Procedure

gene.id

The name of the gene to which GeneSurrounder is applied


sahildshah1/gene-surrounder documentation built on May 27, 2019, 7:27 a.m.