FindBridgeAnchor | R Documentation |
First, bridge object is used to reconstruct two single-modality profiles and
then project those cells into bridage graph laplacian space.
Next, find a set of anchors between two single-modality objects. These
anchors can later be used to integrate embeddings or transfer data from the reference to
query object using the MapQuery
object.
FindBridgeAnchor(
object.list,
bridge.object,
object.reduction,
bridge.reduction,
anchor.type = c("Transfer", "Integration"),
reference = NULL,
laplacian.reduction = "lap",
laplacian.dims = 1:50,
reduction = c("direct", "cca"),
bridge.assay.name = "Bridge",
reference.bridge.stored = FALSE,
k.anchor = 20,
k.score = 50,
verbose = TRUE,
...
)
object.list |
A list of Seurat objects |
bridge.object |
A multi-omic bridge Seurat which is used as the basis to represent unimodal datasets |
object.reduction |
A list of dimensional reductions from object.list used to be reconstructed by bridge.object |
bridge.reduction |
A list of dimensional reductions from bridge.object used to reconstruct object.reduction |
anchor.type |
The type of anchors. Can be one of:
|
reference |
A vector specifying the object/s to be used as a reference during integration or transfer data. |
laplacian.reduction |
Name of bridge graph laplacian dimensional reduction |
laplacian.dims |
Dimensions used for bridge graph laplacian dimensional reduction |
reduction |
Dimensional reduction to perform when finding anchors. Can be one of:
|
bridge.assay.name |
Assay name used for bridge object reconstruction value (default is 'Bridge') |
reference.bridge.stored |
If refernece has stored the bridge dictionary representation |
k.anchor |
How many neighbors (k) to use when picking anchors |
k.score |
How many neighbors (k) to use when scoring anchors |
verbose |
Print messages and progress |
... |
Additional parameters passed to |
Bridge cells reconstruction
Find anchors between objects. It can be either IntegrationAnchors or TransferAnchor.
Returns an AnchorSet
object that can be used as input to
IntegrateEmbeddings
.or MapQuery
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