#' Whole blood reference of 333 tsDHS-DMCs and 7 blood cell subtypes
#'
#' Reference-based cell-type fraction estimation algorithms rely on a prior
#' defined reference matrix. We leveraged cell-type specific DNAse Hypersensitive
#' Site (DHS) information from the NIH Epigenomics Roadmap, and used 450k purified
#' blood cell types dataset from Reinius et al (2012) to construct this
#' improved whole blood reference DNA methylation dataset, as described in
#' Teschendorff et al (2017). It contains 333 tsDHS-DMCs of 7 blood cell
#' subtypes(\emph{As the fractions of eosinophils are usually small, you could
#' add the estimated fractions of neutrophils and eosinophils togetther as the
#' estimations of granulocytes.}):
#'
#' \itemize{
#' \item B-cells
#' \item CD4+ T-cells
#' \item CD8+ T-cells
#' \item NK-cells
#' \item Monocytes
#' \item Neutrophils
#' \item Eosinophils
#' }
#'
#' @docType data
#' @keywords datasets
#' @name centDHSbloodDMC.m
#' @usage data(centDHSbloodDMC.m)
#' @format A matrix with 333 rows and 7 columns
#' @references
#' Teschendorff AE, Breeze CE, Zheng SC, Beck S.
#' \emph{A comparison of reference-based algorithms for correcting cell-type
#' heterogeneity in Epigenome-Wide Association Studies.}
#' BMC Bioinformatics (2017) 18: 105.
#' doi:\href{https://doi.org/10.1186/s12859-017-1511-5}{
#' 10.1186/s12859-017-1511-5}.
#'
#' Reinius LE, Acevedo N, Joerink M, Pershagen G, Dahlen S-E, Greco D,
#' Soderhall C, Scheynius A, Kere J.
#' \emph{Differential DNA methylation in purified human blood cells:
#' implications for cell lineage and studies on disease susceptibility.}
#' PLoS ONE (2012) 7: e41361.
#' doi:\href{https://doi.org/10.1371/journal.pone.0041361}{
#' 10.1371/journal.pone.0041361}.
#'
NULL
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