In smitdave/MASH: MASH (Modular Analysis and Simulation for Human Health)

How does LOME work?

1. Infections begin when mosquitoes probe prior to blood feeding. LOME defines the function probeHost(ixH, spz, t, x, y, MosqPf);

ixH :: the index of the host being probed spz :: the mosquitoes sporozoite status (TRUE/FALSE) t, x, y :: the time and location of the bite MosqPf :: an object with information about Pf in the mosquito

The probeHost algorithm does the following

a. counts the bite (hbr)
b. if (spz == TRUE) - counts the infectious bite (eir) - draws a random # of sporozoites passed - determines survival of sporozoites from non-specific responses - identify the clonal recombinant of each SPZ - get the SPZ PE types - reduce # for type-specific PE immunity - count nSPZ reaching the liver - reduce # for type-specific liver immunity c. if(nSPZ>0) add each spz clone to the eventQ and pedigree

1. The human object activates an infection from the eventQ a. create the time course for the infection & (possibly) queue fever

2. Modifies the time course of other infections

3. Updating the model requires

4. updateImmunity
5. updateInfection

6. OPTIONAL: updateHistory

7. When a mosquito takes a bloodmeal

8. draw a random number to infect mosquito
9. If infected a. how many oocysts form?
   b. return the PfID of each parent

NOTES:

1. Get the tent function working
2. Get prInfectMosquito working (generic)

3. Get infectMosquito working

4. Mosquito bite to bloodstream infection

5. Asexual blood stage infection to gametocytes a. fever & disease b. immunity (affecting future infections) c. gametocytogenesis

6. Mature gametocytes to mosquito infection

Three models to get running:

1. The basic queueing model, with the PfTentTimeCourse 1a. with fever 1b. with treatment

smitdave/MASH documentation built on May 30, 2019, 5:02 a.m.