ixH :: the index of the host being probed spz :: the mosquitoes sporozoite status (TRUE/FALSE) t, x, y :: the time and location of the bite MosqPf :: an object with information about Pf in the mosquito
The probeHost algorithm does the following
a. counts the bite (hbr)
b. if (spz == TRUE)
- counts the infectious bite (eir)
- draws a random # of sporozoites passed
- determines survival of sporozoites from non-specific responses
- identify the clonal recombinant of each SPZ
- get the SPZ PE types
- reduce # for type-specific PE immunity
- count nSPZ reaching the liver
- reduce # for type-specific liver immunity
c. if(nSPZ>0) add each spz clone to the eventQ and pedigree
Modifies the time course of other infections
Updating the model requires
OPTIONAL: updateHistory
When a mosquito takes a bloodmeal
Get infectMosquito working
Mosquito bite to bloodstream infection
Asexual blood stage infection to gametocytes a. fever & disease b. immunity (affecting future infections) c. gametocytogenesis
Mature gametocytes to mosquito infection
Three models to get running:
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