PfMOI.Parameters: Initialize PfMOI Module Parameters

Description Usage Arguments Value Examples

Description

This is mostly used to modify PfMOI parameters for different human populations after creation by using set_PfMOI_PAR method of HumanPop

Usage

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PfMOI.Parameters(InteractionPf = 0, MosyMaxI = 1L, HumanMaxI = 1L,
  Pf_c = 0.15, Pf_b = 0.55, DurationPf = 200, LatentPf = 10,
  FeverPf = 0.3, mnFeverPf = 10, vrFeverPf = 0.1, TreatPf = 0.5,
  mnTreatPf = 3, mnChemoprophylaxisPf = 32, PEProtectPf = 0.99,
  peBlockPf = 1, mnPEPf = 270, vrPEPf = 50, GSProtectPf = 1,
  gsBlockPf = 0.9, mnGSPf = 180, vrGSPf = 20, rdtSensPf = 0.9,
  rdtSpecPf = 0.1, lmSensPf = 0.9, lmSpecPf = 0.1)

Arguments

InteractionPf

if using pathogen interaction model of clearance this parameter control strength of interaction

  • 0: no interaction (reduces to independent clearance)

  • <0: facilitation against host immune system (slower clearance rate than independent queueing)

  • 0<: competition for host resources (faster clearance rate than independent queueing)

  • See https://doi.org/10.1186/1475-2875-8-87 for details of queueing model with pathogen interaction.

MosyMaxI

maximum number of clonal variants passed in single mosquito to human transmission event (set to -1L for unlimited)

HumanMaxI

maximum number of clonal variants passed in single human to mosquito transmission event (set to -1L for unlimited)

Pf_c

infected human to mosquito transmission efficiency

Pf_b

infected mosquito to human transmission efficiency

DurationPf

duration of infection (assuming clonal variants are cleared independently)

LatentPf

latency (How many days after the infectious bite does the infection start?)

FeverPf

probability of fever

mnFeverPf

mean of timing of fever incident relative to start of PfMOI infection (log-normally distributed, mean on natural scale)

vrFeverPf

standard deviation of timing of fever incident relative to start of PfMOI infection (log-normally distributed, standard deviation on natural scale)

TreatPf

probability of treatment after fever incident

mnTreatPf

average waiting time from fever to treatment (exponentially distributed)

mnChemoprophylaxisPf

constant period of proteection from chemoprophylaxis

PEProtectPf

proportion protected by PE vaccination (probability vaccination successful)

peBlockPf

proportion of infections blocked by PE vaccination

mnPEPf

mean duration of protection from PE vaccination

vrPEPf

standard deviation of protection from PE vaccination

GSProtectPf

proportion protected by GS vaccination (probability vaccination successful)

gsBlockPf

proportion of infections blocked by GS vaccination

mnGSPf

mean duration of protection from GS vaccination

vrGSPf

standard deviation of protection from GS vaccination

rdtSensPf

RDT sensitivity

rdtSpecPf

RDT specificity

lmSensPf

Light Microscopy sensitivity

lmSpecPf

Light Microscopy specificity

Value

return a list

Examples

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smitdave/MASH documentation built on May 30, 2019, 5:02 a.m.