Description Usage Arguments Value Examples
Tests the power to detect a burden difference using de novo data varying relative risk.
1 2 | plotDnBurdenByRelativeRisk(R, N, r = 1, q, f, p_thres_denovo_burden = 0.05,
name = "Test", col = "#e41a1c")
|
R |
Maximum relative risk (numeric). |
N |
Sample size (integer). |
r |
Case:Control ratio (numeric). |
q |
Number of functional rare variants per person in selected regions (integer). |
f |
Proportion of functional rare variants that mediate risk for the disorder (numeric, 0-1). |
p_thres_denovo_burden |
p-value threshold after correction for multiple comparisons (numeric, 0-1). |
name |
Prefix for plot filenames (text). |
col |
Color of the line (hex). |
A PDF showing the estimated statistical power as the relative risk is varied.
1 2 3 4 5 6 7 8 9 | R <- 25
N <- 5000
r <- 1
q <- 0.0249
f <- 0.2
p_thres_denovo_burden <- 0.05 / 1000
name <- "Test1"
col <- "#e41a1c"
plotDnBurdenByRelativeRisk()
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