pk_: Algebraic equations for PK models

In tdmore-dev/tdmore: In silico evaluation of precision dosing

Description

Algebraic equations for PK models

Usage

pk1cptiv_(t, A1 = 0, TIME, AMT, V, K, SS = 0, II = Inf)

pk1cptinfusion_(t, A1 = 0, TIME, AMT, RATE, V, K, SS = 0, II = Inf)

pk1cptoral_(t, A0 = 0, A1 = 0, TIME, AMT, V, K, KA, SS = 0, II = Inf)

pk2cptiv_(t, A1 = 0, A2 = 0, TIME, AMT, V, K, K12, K21, SS = 0, II = Inf)

pk2cptinfusion_(
  t,
  A1 = 0,
  A2 = 0,
  TIME,
  AMT,
  RATE,
  V,
  K,
  K12,
  K21,
  SS = 0,
  II = Inf
)

pk2cptoral_(
  t,
  A0 = 0,
  A1 = 0,
  A2 = 0,
  TIME,
  AMT,
  V,
  K,
  KA,
  K12,
  K21,
  SS = 0,
  II = Inf
)

pk3cptiv_(
  t,
  A1 = 0,
  A2 = 0,
  A3 = 0,
  TIME,
  AMT,
  V,
  K,
  K12,
  K21,
  K13,
  K31,
  SS = 0,
  II = Inf
)

pk3cptinfusion_(
  t,
  A1 = 0,
  A2 = 0,
  A3 = 0,
  TIME,
  AMT,
  RATE,
  V,
  K,
  K12,
  K21,
  K13,
  K31,
  SS = 0,
  II = Inf
)

pk3cptoral_(
  t,
  A0 = 0,
  A1 = 0,
  A2 = 0,
  A3 = 0,
  TIME,
  AMT,
  V,
  K,
  KA,
  K12,
  K21,
  K13,
  K31,
  SS = 0,
  II = Inf
)

Arguments

t	sampling times
A1	initial state for A1 at TIME
TIME	dosing time
AMT	dosing amount
V	volume of distribution
K	elimination constant
SS	0 for no steady-state, 1 for steady-state
II	inter-dose interval, required for steady-state calculations
RATE	infusion rate
A0	initial state for A0 at TIME
KA	absorption constant
A2	initial state for A2 at TIME
K12	transfer rate from central compartment to peripheral compartment A
K21	transfer rate from peripheral compartment A to central compartment
A3	initial state for A3 at TIME
K13	transfer rate from central compartment to peripheral compartment B
K31	transfer rate from peripheral compartment B to central compartment

Value

vector of same size as 't', with the concentrations

tdmore-dev/tdmore documentation built on Jan. 1, 2022, 3:21 a.m.