suppressMessages({ suppressPackageStartupMessages({ library(YESCDS) library(tibble) library(dplyr) library(plotly) library(ggplot2) library(ggbeeswarm) library(DT) data(woncan_meta) data(woncan) littab = woncan |> select(MSA, `Cancer Sites`, Age.Adjusted.Rate) |> as.data.frame() }) })
Despite massive investments in cancer research and treatment development, cancer remains a leading cause of death
We have examined many aspects of cancer's diversity
The main modalities of medical response to cancer are
Each of these modalities has a collection of subtypes, and they are often used in combination
How do doctors and patients navigate the available options?
The "gold standard" for evidence in medical decisionmaking is the randomized clinical trial (RCT)
D.1.1 What is the current standard of care?
D.1.2 What care outcomes do we want to improve, and how much improvement would count as a real advance? (Here risk-benefit comparison becomes important)
D.1.3 What is the proposed alternative?
D.1.4 How do we determine a safe "dose" of the proposed alternative? (In the case of surgery this question may not make sense)
D.1.5 How do we verify that the proposed alternative has any effect at all?
D.1.6 How do we measure the overall benefit conferred by using the alternative method?
D.1.1 D.1.2 D.1.3 D.1.4 D.1.5 D.1.6
The concept of informed consent is central in the implementation of clinical trials.
The Belmont report defined principles and guidelines for all human subjects research.
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