Calc_elimination_rate: Calculate the elimination rate for a one compartment model.

In wwiecek/httkgui: High-Throughput Toxicokinetics: Analtica Laser prototype

Description

This function calculates an elimination rate from the three compartment steady state model where elimination is entirely due to metablism by the liver and glomerular filtration in the kidneys.

Usage

calc_elimination_rate(chem.cas=NULL,chem.name=NULL,parameters=NULL,species="Human",
                      suppress.messages=F,default.to.human=F)

Arguments

chem.name	Either the chemical name or the cas number must be specified.
chem.cas	Either the cas number or the chemical name must be specified.
parameters	Chemical parameters from parameterize_steadystate or 1compartment function, overrides chem.name and chem.cas.
species	Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").
suppress.messages	Whether or not the output message is suppressed.
default.to.human	Substitutes missing animal values with human values if true.

Details

When species is specified as rabbit, dog, or mouse, the function uses the appropriate physiological data(volumes and flows) but substitues human fraction unbound, partition coefficients, and intrinsic hepatic clearance.

Value

Elimination rate

Units of 1/h.

Author(s)

John Wambaugh

Examples

calc_elimination_rate(chem.name="Bisphenol A")
calc_elimination_rate(chem.name="Bisphenol A",species="Rat")
calc_elimination_rate(chem.name="Bisphenol A",species="Rabbit")
calc_elimination_rate(chem.cas="80-05-7")

wwiecek/httkgui documentation built on May 15, 2019, 6:31 p.m.