calc_total_clearance: Calculate the total clearance.
In wwiecek/httkgui: High-Throughput Toxicokinetics: Analtica Laser prototype

Description Usage Arguments Details Value Author(s) Examples

This function calculates the total clearance rate for a one compartment model where clearance is entirely due to metablism by the liver and glomerular filtration in the kidneys, identical to clearance of three compartment steady state model.

1 2	calc_total_clearance(chem.cas=NULL,chem.name=NULL,parameters=NULL,species="Human", suppress.messages=F,default.to.human=F)

`chem.name`	Either the chemical name, CAS number, or the parameters must be specified.
`chem.cas`	Either the chemical name, CAS number, or the parameters must be specified.
`parameters`	Chemical parameters from parameterize_steadystate function, overrides chem.name and chem.cas.
`species`	Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").
`suppress.messages`	Whether or not the output message is suppressed.
`default.to.human`	Substitutes missing animal values with human values if true.

When species is specified as rabbit, dog, or mouse, the function uses the appropriate physiological data(volumes and flows) but substitues human fraction unbound, partition coefficients, and intrinsic hepatic clearance.

Total Clearance

Units of L/h/kg BW.

John Wambaugh