calc_hepatic_clearance: Calculate the hepatic clearance.
In wwiecek/httkgui: High-Throughput Toxicokinetics: Analtica Laser prototype

Description Usage Arguments Details Value Author(s) Examples

This function calculates the hepatic clearance for a well-stirred model or other type if specified.

1 2	calc_hepatic_clearance(chem.name=NULL,chem.cas=NULL,parameters=NULL,species='Human', hepatic.model='well-stirred',suppress.messages=F)

`chem.name`	Either the chemical name, CAS number, or the parameters must be specified.
`chem.cas`	Either the chemical name, CAS number, or the parameters must be specified.
`species`	Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").
`parameters`	Chemical parameters from parameterize_steadystate function, overrides chem.name and chem.cas.
`hepatic.model`	Model used in calculating hepatic clearance, unscaled, parallel tube, dispersion, or default well-stirred.
`suppress.messages`	Whether or not to suppress the output message.

When species is specified as rabbit, dog, or mouse, the function uses the appropriate physiological data(volumes and flows) but substitues human fraction unbound, partition coefficients, and intrinsic hepatic clearance.

Hepatic Clearance

Units of L/h/kg BW.

John Wambaugh