Calc_ratioblood2plasma: Calculate the constant ratio of the blood concentration to...

In wwiecek/httkgui: High-Throughput Toxicokinetics: Analtica Laser prototype

Description

This function calculates the constant ratio of the blood concentration to the plasma concentration. It uses the hematocrit and the red blood cell (RBC) parition coefficient as predicted by the Schmitt (2008) method.

Usage

calc_rblood2plasma(chem.cas=NULL, chem.name=NULL, default.to.human=F, species="Human")

Arguments

chem.name	Either the chemical name or the CAS number must be specified.
chem.cas	Either the CAS number or the chemical name must be specified.
default.to.human	Substitutes missing animal values with human values if true.
species	Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").

Details

When species is specified as rabbit, dog, or mouse, the function uses the appropriate physiological data(volumes and flows) but substitues human fraction unbound, partition coefficients, and intrinsic hepatic clearance.

Author(s)

John Wambaugh

References

Schmitt W. "General approach for the calculation of tissue to plasma partition coefficients." Toxicology In Vitro, 22, 457-467 (2008).

Examples

calc_rblood2plasma(chem.name="Bisphenol A")
calc_rblood2plasma(chem.name="Bisphenol A",species="Rat")

wwiecek/httkgui documentation built on May 15, 2019, 6:31 p.m.