assignCellType: Align cell types when reference proportions are known

In ziyili20/TOAST: Tools for the analysis of heterogeneous tissues

Align cell types when reference proportions are known

Description

Align target proportions with reference proportions by pearson correlation coefficients.

Usage

assignCellType(input,reference)

Arguments

input	Input proportiona matrix of dimension N by K.
reference	Reference proportion matrix of dimension N by K.

Value

The aligned proportion matrix, following the cell type ordering of reference proportion matrix.

Author(s)

Ziyi Li <[e-mail]>

References

Ziyi Li, Zhijin Wu, Peng Jin, Hao Wu. "Dissecting differential signals in high-throughput data from complex tissues."

Examples

## generate estimated proportion matrix
estProp <- matrix(abs(runif(50*4,0,1)), 50, 4)
estProp <- sweep(estProp, 1, rowSums(estProp), "/")

## generate reference proportion matrix
refProp <- matrix(abs(runif(50*4,0,1)), 50, 4)
refProp <- sweep(refProp, 1, rowSums(refProp), "/")

estProp_aligned = assignCellType(input = estProp,
reference = refProp)

ziyili20/TOAST documentation built on Aug. 28, 2022, 11:28 a.m.