ExonTesting: "ExonTesting"
In GDS: Genome-Wide Differential Splicing Detection

The ExonTesting function performs a t-test on the array score of predefined groups. If specified, probesets are filtered out on exon scores and test significance.

1 2	ExonTesting(Data, Exonthreshold = NULL, groups = list(group1 = NULL, group2 = NULL), paired = FALSE, significancelevel = NULL)

`Data`	The Data on which testing of the array scores should be conducted. This is preferably output of the GDS function
`Exonthreshold`	The exon score threshold to be maintained. If not NULL, probesets with an exon score lower than this value are not considered further and the p-values will be adjusted for multiplicity after testing. If NULL, all probesets are considered and a multiplicity correction is not performed.
`groups`	A list with two elements speficifing the columns of the data of group 1 in group1 and those of group 2 in group2.
`paired`	Logical. Are the groups paired? If TRUE the mean paired differences are calculated and tested whether these are significantly different from zero or not.
`significancelevel`	The significance level to be maintained on the p-values. The filtering on the significance is conducted only if an Exonthreshold is specified and the p-value are adjusted for multiplicity.

A data frame with one line per exon. The columns contain the gene ID, the exon ID, the test statistic, a p-value and an adjusted p-value. If the groups are paired also the mean paired difference is given. The p-values are adjusted for multiplicity and filtered on significance if significancelevel is not NULL.

GDS documentation built on May 2, 2019, 6:09 p.m.