Description Usage Arguments Value Author(s) Examples
Simulate copy number data for a case-control study.
1 | simul(n, nbSNP, probCas, nbSeg, meanSegmentSize, prob, alpha = 15)
|
n |
Number of individuals. |
nbSNP |
Size of the DNA sequence. |
probCas |
Probability to be a case individual. |
nbSeg |
Number of causal segments. |
meanSegmentSize |
The mean size of anormal segment. |
prob |
A 2*2 matrix containing probabilities: prob[1,1]=probability to have an anomaly to a SNP given the person does not have the disease and the SNP is causal. prob[1,2]=probability to have an anomaly to a SNP given the person does not have the disease and the SNP is not causal. prob[2,1]=probability to have an anomaly to a SNP given the person has the disease and the SNP is causal. prob[2,2]=probability to have an anomaly to a SNP given the person has the disease and the SNP is not causal. |
alpha |
Parameter of the beta(alpha,alpha). |
a list containing:
data |
A matrix of size n*nbSeg, containing values of the copy-number signal. |
response |
A vector of size n containing the cas/control status. |
causalSNP |
A vector of size nbSeg containing the center of causal segments. |
Quentin Grimonprez, Serge Iovleff
1 |
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