arf3DS4-package: Activated Region Fitting fMRI data analysis

Description Details Quick start Example data Author(s) References


Activated Region Fitting (ARF) is an analysis method for fMRI data. The ARF method uses Gaussian shaped functions to model active brain regions. An entire fMRI volume can be described by multiple parameterized Gaussian regions of activation. This parameterization allows for hypotheses on the location of an active region, the spatial extent of an active region, and the amplitude of an active region. ARF can be invoked after standard GLM analysis, and uses the beta-values or t-values from this analysis. In addition ARF can be used to estimate functional connectivity, for this the raw time-series (on which the GLM was performed) are also needed. The arf3DS4 package can read and write fMRI data in Nifti format ( It is build to be compatible with fMRI analysis packages (e.g. FSL or SPM). The package uses a predefined directory- and file-structure to store its data. All objects (S4-class) and fMRI data files are stored in this directory- and file-structure.


Package: arf3DS4
Type: Package
Version: 2.5-4
Date: 2011-10-28
Depends: R (>= 2.12.0), methods, graphics, tcltk
Repository/R-Forge/Revision: 203
Publication: 2011-10-28 12:38:50
Packaged: 2011-10-28 12:38:50; rforge
Built: R 2.12.0; universal-apple-darwin9.8.0; 2011-10-28 12:38:50; unix
LazyLoad: yes

Quick start

The main directory- and file-structure (termed an experiment) is handled by an object of class experiment. To make an empty experiment structure call makeExpDirs. This will create a directory- and file-structure to hold the fMRI data (which will have to be copied manually to the appropriate directories, see data for an overview of the data-directories ). Once this is done an experiment is loaded by calling loadExp. To fit the ARF models (class model) to the data, first create a model using newModel, adjust the options of the model via the options-object using loadOptions and saveOptions, and finally fit the model using fitModel. To perform hypothesis tests call varcov and wald to calculate the parameter (co)variance matrix and Wald statistics respectively. In addition to the hypothesis test connectivity between brain regions can be estimated (call fitConnectivity to perform this analysis). This function requires that the raw time-series of the fMRI data are available and that single-trial estimates (call makeSingleTrialEvents) are calculated.

Example data

The package comes with an example dataset (load it using data("arf-example-data")). By then calling makeExample, a directory-structure containing the example data is then created and loaded. Call getExp to view the data within the experiment.


Wouter D. Weeda <[email protected]>


Wouter D. Weeda, Lourens J. Waldorp, Ingrid Christoffels and Hilde M. Huizenga (2009). Activated Region Fitting: A Robust High-Power Method for fMRI Analysis Using Parameterized Regions of Activation. Human Brain Mapping, 30(8), 2595-2605.
Wouter D. Weeda, Lourens J. Waldorp, Raoul P.P.P. Grasman, Simon van Gaal and Hilde M. Huizenga (2011). Functional Connectivity Analysis of fMRI Data Using Parameterized Regions of Interest. NeuroImage, 54(1), 410-416.
Wouter D. Weeda, Frank de Vos, Lourens J. Waldorp, Raoul P.P.P. Grasman, Hilde M. Huizenga (2011). arf3DS4: An Integrated Framework for Localization and Connectivity Analysis of fMRI Data. Journal of Statistical Software, 44(14), 1-33. URL

arf3DS4 documentation built on May 31, 2017, 2:59 a.m.