BiFET identifies TFs whose footprints are over-represented in target regions compared to background regions after correcting for the bias arising from the imbalance in read counts and GC contents between the target and background regions. For a given TF k, BiFET tests the null hypothesis that the target regions have the same probability of having footprints for the TF k as the background regions while correcting for the read count and GC content bias. For this, we use the number of target regions with footprints for TF k, t_k as a test statistic and calculate the p-value as the probability of observing t_k or more target regions with footprints under the null hypothesis.
Package details |
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Author | Ahrim Youn [aut, cre], Eladio Marquez [aut], Nathan Lawlor [aut], Michael Stitzel [aut], Duygu Ucar [aut] |
Bioconductor views | ATACSeq DNaseSeq Epigenetics GeneRegulation Genetics ImmunoOncology RIPSeq Software Transcription |
Maintainer | Ahrim Youn <Ahrim.Youn@jax.org> |
License | GPL-3 |
Version | 1.10.0 |
Package repository | View on Bioconductor |
Installation |
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