rrbs: RRBS data of APL patient samples and controls.

In BiSeq: Processing and analyzing bisulfite sequencing data

Description

RRBS data of the CpG sites CpG sites from genomic regions on p arms of chromosome 1 and 2 covered in at least one sample. Data was obtained from 5 APL patient samples and 5 control samples (APL in remission). RRBS data was preprocessed with the Bismark software version 0.5.

Usage

rrbs

Format

A BSraw-class object.

Source

Schoofs T, Rohde C, Hebestreit K, Klein HU, Goellner S, Schulze I, Lerdrup M, Dietrich N, Agrawal-Singh S, Witten A, Stoll M, Lengfelder E, Hofmann WK, Schlenke P, Buechner T, Hansen K, Berdel WE, Rosenbauer F, Dugas M, Mueller-Tidow C (2012). DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding. Blood.

References

Krueger F, Andrews SR. Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. Bioinformatics. 2011;27:1571-1572.

Examples

data(rrbs)
show(rrbs)

BiSeq documentation built on Nov. 8, 2020, 8:05 p.m.