DIAlignR: Dynamic Programming Based Alignment of MS2 Chromatograms

To obtain unbiased proteome coverage from a biological sample, mass-spectrometer is operated in Data Independent Acquisition (DIA) mode. Alignment of these DIA runs establishes consistency and less missing values in complete data-matrix. This package implements dynamic programming with affine gap penalty based approach for pair-wise alignment of analytes. A hybrid approach of global alignment (through MS2 features) and local alignment (with MS2 chromatograms) is implemented in this tool.

Package details

AuthorShubham Gupta <shubham.1637@gmail.com>, Hannes Rost <hannes.rost@utoronto.ca>
Bioconductor views Alignment MassSpectrometry Metabolomics Proteomics Software
MaintainerShubham Gupta <shubham.1637@gmail.com>
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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DIAlignR documentation built on Nov. 8, 2020, 8:22 p.m.