GEM-package: GEM: Fast association study for the interplay of Gene,...

In GEM: GEM: fast association study for the interplay of Gene, Environment and Methylation

Description

The GEM package provides a highly efficient R tool suite for performing epigenome wide association studies (EWAS). GEM provides three major functions named GEM_Emodel, GEM_Gmodel and GEM_GxEmodel to study the interplay of Gene, Environment and Methylation (GEM). Within GEM, the existing "Matrix eQTL" package is utilized and extended to study methylation quantitative trait loci (methQTL) and the interaction of genotype and environment (GxE) to determine DNA methylation variation, using matrix based iterative correlation and memory-efficient data analysis. GEM can facilitate reliable genome-wide methQTL and GxE analysis on a standard laptop computer within minutes.

Author(s)

Hong Pan

References

https://github.com/fastGEM/GEM

See Also

GEM_GUI

Examples

## Launch GEM GUI
#GEM_GUI()  # remove the hash symbol for running

## Checking the vignettes for more details
if(interactive()) browseVignettes(package = 'GEM')

GEM documentation built on Nov. 8, 2020, 5:02 p.m.