Description Usage Arguments Value Author(s) See Also Examples

'par2lambda' takes list of lm coefficient names and a corresponding list of numeric vectors corresponding to hypothesis tests of linear contrasts and returns a lambda matrix suitable for an F-test of the linear contrasts. 'par2lambda' is intended to be used in conjunction with 'contrastTest' or 'findFC'.

'contrastTest' performs an F test for simultaneous tests of linear contrasts using an appropriately specified lambda matrix and an lm object.

1 2 | ```
par2lambda(betaNames, betas, coefs)
contrastTest(model, lambda, cVec = NA, p = 0.01)
``` |

`betaNames` |
A character vector of the names of the coefficients in a linear model. |

`betas` |
A list of vectors of the parameters to be used in the contrasts. |

`coefs` |
A list of vectors of numeric coefficients corresponding to betas. |

`model` |
An lm object. |

`lambda` |
A matrix of coefficients in the appropriate order to be multiplied by the estimated coefficients of the lm object, possibly returned from 'par2lambda'. |

`cVec` |
A vector of constants for testing that the linear contrasts equal something other than zero. If this is unspecified, it is assumed to be zero. |

`p` |
The significance level at which to perform the contrast test. |

For `par2lambda`

: A lambda matrix constructed for testing linear contrasts using lm output.

For `contrastTest`

:

`test ` |
Returns "REJECT" or "FAIL TO REJECT" based on the result of the test of hypothesis. |

`Fstat` |
The F statistic for the test of contrast. |

`pvalue` |
The corresponding pvalue for the F test. |

`cEst` |
The contrast estimate. |

Denise Scholtens

1 2 3 4 5 6 7 8 9 | ```
data(estrogen)
ES <- pData(estrogen)[["ES"]]
TIME <- pData(estrogen)[["TIME"]]
fit <- lm(exprs(estrogen)["40079_at",] ~ ES + TIME + ES*TIME)
betaNames <- names(coef(fit))
betas <- list(c("ESP"),c("ESP","ESP:TIME48h"))
coefs <- list(c(1),c(1,1))
lambda <- par2lambda(betaNames,betas,coefs)
contrastTest(fit,lambda)
``` |

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