Z-scores of values for a variety of assays conducted on the NCI-60 to facilitate comparison. Z-scores calculated over the 60 cell lines for the given feature.
A list containing various assay values:
cop Copy number values; Described in Pubmed ID: 24670534
exp Expression values; Obtained from "RNA: 5 Platform Gene Transcript" http://discover.nci.nih.gov/cellminer/loadDownload.do; Missing values imputed using the R package "impute"
mut Mutation values; Deleterious mutations obtained from TODO
mir MicroRNA values; Obtained from "RNA: Agilent Human microRNA (V2)" http://discover.nci.nih.gov/cellminer/loadDownload.do
pro Reverse protein lysate array values; Obtain from "Protein: Lysate Array" http://discover.nci.nih.gov/cellminer/loadDownload.do
mda NCI-60 metadata.
CNV_GAIN Proportion of genome copy number gains; Described in Pubmed ID: 24670534
CNV_LOSS Proportion of genome copy number losses; Described in Pubmed ID: 24670534
CNV_TOTAL Sum of CNV_GAIN and CNV_LOSS
P53_BIN Binary TP53 profile curated by William Reinhold
MSI_OGAN_BIN Binary microsatellite instability (MSI) profile curated by Ogan Abaan using COSMIC data; Obtained from Supplementary Table 1 - Ogan Whole Exome Sequencing (WES) paper in Cancer Res.
EPITHELIAL Epithelial by tissue of origin - pattern extracted from the CellMiner cell line metadata http://discover.nci.nih.gov/cellminer/celllineMetadata.do
EPITHELIAL_KURT Kurt Kohn curation for epithelial-like cell lines based on molecular parameters described in Pubmed ID: 24940735
DELETERIOUS Total deleterious variants from WES dataset; Fabricio Sousa curation
MISSENSE Total missense variants from WES dataset; Fabricio Sousa curation
SILENT Total silent variants from WES dataset; Fabricio Sousa curation
TOTAL_AA Total amino acid changing variants from WES dataset; Fabricio Sousa curation
CELL-CELL Cell-to-cell adhesion curated by William Reinhold
DOUBLINGTIME The doubling time pattern was extracted from the CellMiner cell line metadata http://discover.nci.nih.gov/cellminer/celllineMetadata.do
Vinodh Rajapakse vinodh.rajapakse AT nih.gov