ASSISTant is a package that implements a three-stage adaptive clinical trial design with
provision for subgroup selection where the treatment may be effective. The main design object
R6 class that can be instantiated and manipulated to obtain the operating
characteristics. A vignette is provided showing the use of this package for designing the DEFUSE-3
trial, described in the paper by Lai, Lavori and Liao. The package contains everything necessary
to reproduce the results of the paper.
Adaptive Choice of Patient Subgroup for Comparing Two Treatments by Tze Leung Lai and Philip W. Lavori and Olivia Yueh-Wen Liao. Contemporary Clinical Trials, Vol. 39, No. 2, pp 191-200 (2014). http://www.sciencedirect.com/science/article/pii/S1551714414001311
Adaptive design of confirmatory trials: Advances and challenges, http://www.sciencedirect.com/science/article/pii/S1551714415300239 by Tze Leung Lai and Philip W. Lavori and Ka Wai Tsang. Contemporary Clinical Trials, Vol. 45, Part A, pp 93-102 (2015).
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