BICORN: Integrative Inference of De Novo Cis-Regulatory Modules

Prior transcription factor binding knowledge and target gene expression data are integrated in a Bayesian framework for functional cis-regulatory module inference. Using Gibbs sampling, we iteratively estimate transcription factor associations for each gene, regulation strength for each binding event and the hidden activity for each transcription factor.

install.packages("BICORN")

Try the BICORN package in your browser